|
KMID : 0359920120310040249
|
|
Korean Journal of Nephrology
2012 Volume.31 No. 4 p.249 ~ p.252
|
|
|
Acute oxalate nephropathy caused by ethylene glycol poisoning
|
|
Seo Jung-Woong
Lee Jong-Ho
Son In-Sung
Kim Yong-Jin
Kim Do-Young
Hwang Yong
Chung Hyun-Ah
Choi Hong-Seok
Lim So-Dug
|
|
|
Abstract
|
|
|
|
Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, and kidney injury. Oxalic acid is the end product of EG, which can precipitate to crystals of calcium oxalate monohydrate in the tubular lumen and has been linked to acute kidney injury. We report a case of EG-induced oxalate nephropathy, with the diagnosis confirmed by kidney biopsy, which showed acute tubular injury of the kidneys with extensive intracellular and intraluminal calcium oxalate monohydrate crystal depositions.
|
|
|
KEYWORD
|
|
|
Acute kidney injury, Calcium oxalate, Ethylene glycol, Metabolic acidosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|